![]() HRD is not only caused by defects in genes involved in the HRR pathway including BRCA1 and BRCA2 but mechanisms such as promoter methylation resulting in loss of gene expression and other unknown factors may be responsible. These defects in the HRR pathway leads to HR Deficiency (HRD) that results in the development of cancer. Loss-of-function of the genes involved in this pathway results in defective DNA repair and thus accumulates genomic errors. HRR is an error-free DNA repair pathway important for cell survival after exposure to certain cellular stresses like radiation and anticancer agents. It has been estimated that one in 133 women was affected with ovarian cancer in 2020.Ī majority of ovarian cancers occur due to changes in BRCA1/2 genes or the genes involved in the homologous recombination repair (HRR) pathway. ![]() About 70 per cent of ovarian cancers are of high-grade serous type. Ovarian cancer is the third most common gynaecological cancer in India and eighth worldwide, having the worst prognosis with a five-year survival rate of 45 per cent.
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